Cell_Death by Gerry Melino and David Vaux
Programmed Programmed cell death and apoptosis have been assumed to emerge with multicellularity, and to depend onspecific ‘death genes’ whose sole effects are execution or repression of cell death. In 1996, I proposed the ‘original sin’ hypothesis, postulating that the origin of self-destruction is as ancient as the origin of the first cells, and predicting that there are no specific ‘death genes’. Rather, an ancestral and unavoidable capacity of effectors of cell survival – of cell metabolism, differentiation, cycling – to induce cell death favoured their continuous selection during evolution for both their ‘pro-life’ and ‘pro-death’ activities. Diversification of these effectors was accelerated by their recruitment into host/parasite interactions and symbioses, including the one that gave birth to eukaryote cells. The main prediction of the ‘original sin’ hypothesis is supported by recent findings showing that effectors of cell death indeed have previously undetected roles in cell survival.
0 komentar:
Posting Komentar